Lexicon
Chief Longevity Officer
Also known as CLO
Definition
A Chief Longevity Officer is a leadership and clinical role in longevity medicine, the emerging field that aims to promote healthy longevity in the human population by bringing fundamental ageing research together with clinical applications. [1] The role sits within a discipline, sometimes called precision geromedicine, in which interventions are anticipated to be tailored to each person based on their genetic profile, omics-based and clinical biomarkers of aging, psychosocial profile, and past or present exposures. [2]
Field context
Longevity medicine is grounded in geroscience, a discipline that aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases, and increase disability-free survival. [3] Practitioners in this field draw on the integration of generative AI, cutting-edge biological technology, and longevity medicine that is proposed as essential for extending the productive and healthy human lifespan. [1]
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- 1.Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY) · 2024
- 2.Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, Kennedy BK, Rando TA. From geroscience to precision geromedicine: Understanding and managing aging. Cell · 2025
- 3.Kritchevsky SB, Cummings SR. Geroscience: A Translational Review. JAMA · 2025
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